In this piece of work, the ANN approach was applied to analyze TFR in Djibouti. The employed annual data covers the period 1960-2018 and the out-of-sample period ranges over the period 2019-2030. The residuals and forecast evaluation criteria (Error, MSE and MAE) of the applied model indicate that the model is stable in forecasting TFR in Djibouti. The results of the paper indicated that annual total fertility rates in Djibouti are likely to slightly drop over the out-of-sample period. Therefore, authorities in Djibouti are encouraged to focus on improving access to sexual and reproductive health (SRH) services among adolescents and young adults.