International Research Journal of Innovations in Engineering and Technology - IRJIET International Open Access, Monthly, Peer Reviewed, Reputed Journal ISSN (online): 2581-3048

Impact Factor (2025): 6.9

DOI Prefix: 10.47001/IRJIET

Alkylresorcinols as an Indicator of Whole-Grain Intake and Its Relation to Colorectal Carcinoma

Abstract

BACKGROUND: Alkylresorcinols are phenolic lipids that exclusively present in the outer parts of wheat and rye grains. They have been proposed as specific dietary biomarkers of whole-grain wheat and rye intake. Dietary fibers protective role aganist colorectal cancer has been postulated several decades ago. AIM: To verify the relation of dietary fiber intake and incidence of colorectal cancer using plasma total Alkylresorcinols concentrations as an indicator of whole-grain intake. METHODS: 148 Subjects were enrolled and categorixed into two groups; Group (A): 62 patients with colorectal cancer and Group (B): 86 subjects with normal colonoscopy “control group”. Blood samples were withdrawn from the patients after overnight fasting for detection of Alkylresorcinols levels. RESULTS: Detection of the Alkylresorcinols levels; C17, C21 and Total Cs were significantly higher in the control group in comparison to colorectal cancer group, C19 levels showed no significant difference. CONCLUSION: People with high intake of fibers especially cereals probably have a lower risk of developing cancer colon.

Country : Egypt/India

1 Shalaby S.I.2 Mayssa E-Rzky3 Mofeed Shehab4 Dina Sabry5 Ihab K.Abdel-Aziz6 Mohamed AbdAllah7 Omar El Shabacy8 Devendra Kumar Awasthi

  1. Department of Complementary Medicine, Medical Division, National Research Centre, Dokki, Egypt
  2. Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
  3. Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
  4. Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt
  5. Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
  6. Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
  7. Department of Complementary Medicine, Medical Division, National Research Centre, Dokki, Egypt
  8. Department of Chemistry, Sri JN MPG College, Lucknow, India

IRJIET, Volume 6, Issue 4, April 2022 pp. 39-43

doi.org/10.47001/IRJIET/2022.604006

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