This study uses annual time series data on under five mortality rate (U5MR) for Antigua and Barbuda from 1960 to 2020 to predict future trends of U5MR over the period 2021 to 2030. Forecast evaluation criteria of the applied model indicate that the model is stable in forecasting U5MR for Antigua and Barbuda. The ANN (12, 12, 1) model projections suggest that U5MR will hover around 7.0 deaths per 1000 live births over the out of sample period. Therefore, the government should draft child health policies that will keep under five mortality under control.