This study uses annual time series data on under five mortality rate (U5MR) for Jamaica from 1960 to 2020 to predict future trends of U5MR over the period 2021 to 2030. Residuals and forecast evaluation indicate that the applied model is stable in stable in forecasting under five mortality rate. The ANN (12, 12, 1) model projections revealed thatU5MR will continue to decline throughout the out of sample period. Therefore, we encourage the Jamaican government to continue supporting maternal and child health (MNCH) program and address all the challenges that contribute to under five mortality.