The Bhima River is a major river in South India. Along the river stretch there are about 7000 industries comprising large, medium and small-scale units according to CPCB. Most of the industries are located in the Maharashtra Industrial Development Corporation (MIDC). The river is 80 percentage polluted by industries pollution and 20 percentage by domestic wastewater. Based on sampling on various locations, it was found that the river stretches of Bhima River and its tributaries are polluted. River water qual-its models are used extensively in research as well as in the design and assessment of water quality management measures. The application of mathematical models for that purpose dates back to the initial studies of oxygen depletion due to organic waste pollution. Since then, models have been constantly refined and updated to meet new and emerging problems of water pollution. In order to handle the complex interactions caused by the increased influence of human activities in rivers. It is today mandatory to river water quality models with model describing emissions from the drainage and sewerage system. Special attention is given here to the modeling of convergence processes, but also the methods and tools to work with the models i.e., parameter estimation, and simulation software QUAL2E are discussed. QUAL2E is a framework for the simulation of water quality in streams and rivers.