Eco-friendly Synthesis and Characterization of CeO2-doped TiO2 Nanoparticles Using Biowaste: Unveiling Potent Anti-inflammatory and Antioxidant Properties

Abstract

In this study, CeO2-doped TiO2 nanoparticles were synthesized using an eco-friendly approach, utilizing an aqueous extract from the calyx leaves (outer covering) of Physalis peruviana fruits. The morphology of the green-synthesized nanoparticles was characterized using UV-Vis spectroscopy, FT-IR, SEM, and X-ray diffraction. The anti-inflammatory activity of the biosynthesized NPs was evaluated through a denaturation test. The use of the fruit’s outer calyx, commonly discarded as food waste, presents a sustainable strategy for repurposing food and biological waste in nanotechnology. The NPs exhibited favorable magnetic properties, a well-defined crystalline structure, and notable anti-inflammatory effects, highlighting their potential for therapeutic and medical applications, particularly under green synthesis protocols.

Country : India

1 Bhaskar Dwivedi2 Diksha Bhardwaj3 Deepika Choudhary

  1. Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India
  2. Department of Chemistry, S. S. Jain Subodh PG College, Jaipur, Rajasthan, India
  3. Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India

IRJIET, Volume 8, Issue 9, September 2024 pp. 177-182

doi.org/10.47001/IRJIET/2024.809022

References

  1. Malik, S., Muhammad, K., Waheed, Y., 2023. Nanotechnology: A Revolution in Modern Industry. Molecules.28(2), 661.
  2. Lloyd-Hughes, H., Shiatis, A.E., Pabari, A., Mosahebi, A., Seifalian, A., 2015. Current and future nanotechnology applications in the management of melanoma: A review. J. Nanomed. Nanotechnol. 6(6), 1.
  3. Yusuf, A., Almotairy, A.R.Z., Henidi, H., Alshehri, O.Y., Aldughaim, M.S., 2023. Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles’ Physicochemical Properties on Responses in Biological Systems. Polymers.15(7), 1596.
  4. Pelaz, B., Jaber, S., de Aberasturi, D.J., Wulf, V., Aida, T., de la Fuente, J.M., Feldmann, J., Gaub, H.E., Josephson, L., Kagan, C.R., Kotov, N.A., Liz-Marzán, L.M., Mattoussi, H.,Mulvaney, P., Murray, C.B., Rogach, A.L., Weiss, P.S.,Willner, I.,Parak, W.J., 2012. The State of Nanoparticle-based Nanoscience and Biotechnology: Progress, Promises, and Challenges. ACS Nano.6(10), 8468–8483.
  5. Rana, A., Yadav, K., Jagadevan, S., 2020. A Comprehensive Review on Green Synthesis of Nature-Inspired Metal Nanoparticles: Mechanism, Application and Toxicity. J. Clean. Prod. 272, 122880.
  6. Nikolova, M.P., Chavali, M.S., 2020. Metal Oxide Nanoparticles as Biomedical Materials. Biomimetics (Basel).5(2), 27.
  7. Zafar, N., Madni, A., Khalid, A., Khan, T., Kousar, R., Naz, S.S., Wahid, F., 2020. Pharmaceutical and Biomedical Applications of Green Synthesized Metal and Metal Oxide Nanoparticles. Curr. Pharm. Des. 26(45), 5844-5865.
  8. Filho S.A., Dos Santos M.S., Dos Santos, O.A.L., Backx, B.P., Soran, M.L., Opriş, O., Lung, I., Stegarescu, A., Bououdina, M., 2023. Biosynthesis of Nanoparticles Using Plant Extracts and Essential Oils. Molecules. 28(7), 3060.
  9. Ali, I., Suhail, M., Alothman, Z.A., Alwarthan, A., 2018. Recent advances in syntheses, properties and applications of TiO2 nanostructures. RSC Adv.8, 30125-30147.
  10. Ziental, D., Czarczynska-Goslinska, B., Mlynarczyk, D.T., Glowacka-Sobotta, A., Stanisz, B., Goslinski, T., Sobotta, L., 2020. Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine. Nanomaterials (Basel). 10(2), 387.
  11. Pulit-Prociak, J., Długosz, O., Staroń, A., Radomski, P., Domagała, D. and Banach, M., 2023. In vitro studies of titanium dioxide nanoparticles modified with glutathione as a potential drug delivery system. Nanotechnol. Rev.121, 20230126.
  12. Sagadevan, S.; Imteyaz, S.; Murugan, B.; Lett, J.A.; Sridewi, N., Weldegebrieal, G.K., Is, Fatima., Oh, W.-C., 2022. A comprehensive review on green synthesis of titanium dioxide nanoparticles and their diverse biomedical applications. Green Processing and Synthesis.11, 44-63.
  13. Verma, V., Al-Dossari, M., Singh, J., Rawat, M., Kordy, M.G.M., Shaban, M., 2022. A Review on Green Synthesis of TiO2 NPs: Photocatalysis and Antimicrobial Applications. Polymers (Basel).14(7), 1444.
  14. Hsu, C.-Y., Mahmoud, Z.H., Abdullaev, S., Ali, F.K., Naeem, Y.A., Mizher, R.M., Karim, M.M., Abdulwahid, A.S., Ahmadi, Z., Habibzadeh, S., kianfar, E., 2024. Nano titanium oxide (nano-TiO2): A review of synthesis methods, properties, and applications. Case Stud. Chem. Environ. Eng. 9, 100626.
  15. Yabe, S., Yamashita, M., Momose, S., Tahira, K., Yoshida, S., Li, R., Yin S., Sato, T., 2001. Synthesis and UV-shielding properties of metal oxide doped ceria via soft solution chemical processes. Int. J. Inorg. Mater.3, 1003–1008.
  16. Qi, J., Chen, J., Li, G., Li, S., Gao, Y., Tang, Z., 2012. Facile synthesis of core–shell Au@CeO2 nanocomposites with remarkably enhanced catalytic activity for CO oxidation. Energy Environ. Sci.5, 8937– 8941.
  17. Kumar, S.S., Lellala, K., Ashok, M., Priyadharsan, A., Sanjeeviraja, C., Rajendran, A., 2018. Green synthesis of CeO2–TiO2 compound using Cleome chelidonii leaf extract for excellent photocatalytic activity. J. Mater. Sci.: Mater. Electron.29, 14022-14030.
  18. Patra, J.K., Das, G., Shin, H.-S., 2019. Facile green biosynthesis of silver nanoparticles using Pisum sativum L. outer peel aqueous extract and its antidiabetic, cytotoxicity, antioxidant, and antibacterial activity. Int. J. Nanomedicine. 14, 6679–6690.
  19. Gironés-Vilaplana, A., Baenas, N., Villaño, D., Speisky, H., Cristina, G.-V., Moreno, D.A., 2014. Evaluation of Latin-American fruits rich in phytochemicals with biological effects. J. Funct. Foods.7, 599-608.
  20. Castro, J., Ocampo, Y., Franco, L., 2015. Cape Gooseberry [Physalis peruviana L.] Calyces Ameliorate TNBS Acid-induced Colitis in Rats. J. Crohns Colitis. 9(15), 1004–1015.
  21. Sahoo,A.K., Dash, U.C., Kanhar, S., Mahapatra, A.K., 2017. In vitro biological assessment of Homalium zeylanicumand isolation of lucidenic acid a triterpenoid. Toxicol. Rep.4, 274–281.
  22. Miliauskas, G., Venskutonis, P.R., Beek, T.A.V., 2004. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem.85(2), 231–237.
  23. Ameen, S., Akhtar, M.S., Seo, H.-K., Shin, H.-S., 2014. Solution-processed CeO2/TiO2 nanocomposite as potent visible light photocatalyst for the degradation of bromophenol dye. Chem. Eng. J. 247, 193-198.
  24. Bhardwaj, D., Singh, R., 2021. Green biomimetic synthesis of Ag–TiO2 nanocomposite using Origanum majorana leaf extract under sonication and their biological activities. Bioresour. Bioprocess.8, 1.
  25. Yan, B., Zhu, H., 2008. Controlled synthesis of CeO2 nanoparticles using novel amphiphilic cerium complex precursors. J. Nanoparticle Res. 10, 1279–1285.
  26. Al Masoudi, L.M., Alqurashi, A.S., Abu Zaid, A., Hamdi, H., 2023. Characterization and Biological Studies of Synthesized Titanium Dioxide Nanoparticles from Leaf Extract of Juniperus phoenicea (L.) Growing in Taif Region, Saudi Arabia. Processes. 11(1), 272.  
  27. Chaiyo, P., Duangsing, B., Thumthan, O., Nutariya, J., Pukird, S., 2017. Electrical and gas sensing properties of TiO2/GO nanocomposites for CO2 sensor application. J. Phys. Conf. Ser.901, 012095.
  28. Singh, M., Goyal, M., Devlal, K., 2018. Size and shape effects on the band gap of semiconductor compound nanomaterials. J. Taibah Univ. Sci.12, 470–475.
  29. Recio, M.C., Andujar, I., Rios, J.L., 2012. Anti-inflammatory agents from plants: progress and potential. Curr. Med. Chem.19(14), 2088–2103. 
  30. Venkatappa, M.M., Udagani, C., Gowda S.M.H., Venkataramaiah, S., Casini, R., Moussa, I.M., Achur, R., Sannaningaiah, D., Elansary, H.O., 2023. Green Synthesised TiO2 Nanoparticles-Mediated Terenna asiatica: Evaluation of Their Role in Reducing Oxidative Stress, Inflammation and Human Breast Cancer Proliferation. Molecules.28, 5126.
  31. Toro, R.M., Aragón, D.M., Ospina, L.F., Ramos, F.A., Castellanos, L., 2014. Phytochemical analysis, antioxidant and anti-inflammatory activity of calyces from Physalis peruviana. Nat. Prod. Commun. 9, 1573–1575.
  32. Wu, S.J., Tsai, J.Y., Chang, S.P., Lin, D.L., Wang, S.S., Huang, S.N., Ng, L.T., 2006. Supercritical carbon dioxide extract exhibits enhanced antioxidant and anti-inflammatory activities of Physalis peruviana. J. Ethnopharmacol.108, 407–413.
  33. Eriksson, P., Tal, A.A., Skallberg, A., Brommesson, C., Hu, Z., Boyd, R.D., Olovsson, W., Fairley, N., Abrikosov, I.A., Zhang, X. and Uvdal, K., 2018. Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement. Sci. Rep. 8, 6999.